Lecce Cathedral is dedicated to the Assumption of the Virgin Mary. It is the seat of the Archbishop of Lecce. The cathedral was first built in 1144, but underwent repairs in 1230. It was rebuilt in 1659 by the architect Giuseppe Zimbalo by order of Bishop Luigi Pappacoda, whose remains are kept in the altar dedicated to Saint Orontius of Lecce, the patron saint of the city.

The cathedral is located in the centre of the city of Lecce and sits on the southeast corner of the Piazza del Duomo. It is accessible from the piazza through two entrances, one on the north side of the building and another on the west side. The cathedral shares the piazza with other buildings, including the bell tower, the bishop's residence, and the seminary.